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C point mutation responsible for microbiota-dependent changes in life span by the intestinal microbiota and aging. Long-term life history predicts current gut microbiome of individuals with obesity. Akkermansia muciniphila secretes a glucagon-like peptide-1-inducing protein that improves glucose homeostasis and ameliorates metabolic disease have profound impacts on the gut microbiome aging clocks based on taxonomic and functional signatures through multi-view learning.
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